Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

John F. Henry is an eminent economist who has made important contributions to heterodox economics drawing on Adam Smith, Karl Marx, Thorstein Veblen, and John Maynard Keynes. His historical approach offers radical insights into the evolution of ideas (ideologies and theories) giving rise to and/or induced by the changes in capitalist society. Essays collected in this festschrift not only evaluate John Henry's contributions in connection to Marx's and Veblen's theories, but also apply them to the socio-economic issues in (...) the 21st century. In Part I leading heterodox economists in the traditions of Marxism, Post Keynesianism, and Institutionalism critically examine Marx's and Veblen's theoretical frameworks (and their connections to each other) that have become the foundations of heterodox economics. Chapters in Part II showcase alternative theoretical explanations inspired by Marx, Veblen, and Henry. Topics in this Part include financial crisis, financialization, capital accumulation, economics teaching, and the historical relationship between money and class society. Part III is devoted to John Henry's heterodox economics encapsulated in his "farewell" lecture, interview, and bibliography. Essays in this book, individually and collectively, make an important point that the history of economic thought (or historical analysis of economic theory and policy) is an integral part of developing heterodox economics as an alternative theoretical framework. Anyone who is troubled by the recurring failure of capitalism as well as mainstream economics will find this book well worth reading. (shrink)

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

The progress of electronic health technologies and biobanks holds enormous promise for efficient research. Evidence shows that studies based on sharing and secondary use of data/samples have the potential to significantly advance medical knowledge. However, sharing of such resources for international collaboration is hampered by the lack of clarity about ethical and legal requirements for transfer of data and samples across international borders. Here, the International Clinical Trial Center Network reports the legal and ethical requirements governing data and sample exchange (...) across four continents. The most recurring requirement is ethical approval, whereas only in specific conditions approval of national health authorities is required. Informed consent is not required in all sharing situations. However, waiver of informed consent is only allowed in certain countries/regions and under certain circumstances. The current legal and ethical landscape appears to be very complex and under constant evolution. Regulations differ between countries/regions and are often incomplete, leading to uncertainty. With this work, ICN illuminates the unmet need for a single international collaborative framework to facilitate DSE. Harmonising requirements for global DSE will reduce inefficiency and waste in research. There are many challenges to realising this ambitious vision, including inconsistent terminology and definitions, and heterogeneous and dynamic legal constraints. Here, we identify areas of agreement and significant difference as a necessary first step towards facilitating international collaboration. We propose the establishment of a working group to continue the comparison across jurisdictions, create a standardised glossary and define a set of basic principles and fundamental requirements for DSE. (shrink)

We provide a retrospective of 25 years of the International Conference on AI and Law, which was first held in 1987. Fifty papers have been selected from the thirteen conferences and each of them is described in a short subsection individually written by one of the 24 authors. These subsections attempt to place the paper discussed in the context of the development of AI and Law, while often offering some personal reactions and reflections. As a whole, the subsections build into (...) a history of the last quarter century of the field, and provide some insights into where it has come from, where it is now, and where it might go. (shrink)

Engaging Eriugena, Eckhart and Cusanus contains two new essays and nine others published between 2005 and 2019. The essays explore Eriugena, Eckhart and Cusanus as bold thinkers deeply engaged with their times and culture. John Scottus Eriugena, Meister Eckhart and Nicholas of Cusa are key figures in the medieval Christian Neoplatonic tradition. This book focuses on their engagement with practical, experiential issues and controversies. Eriugena revises Genesis' Adam and Eve narrative and makes sexual difference and overcoming it central to his (...) Periphyseon. Eckhart's Annunciation sermons urge his hearers to give birth to God's son within their lives, and he develops a distinctive approach to pain and suffering. His radical preaching on the Eucharist and mystical union was judged heretical, but was later taken up by Nicholas of Cusa. Coins and banking became key symbols in Cusanus' exploration of humanity as created in God's image, and he used mechanical clocks in reflecting on time and eternity. 'Engagement' also describes these thinkers' reception of their predecessors and how later readers appropriated their works. Eriugena struggled with the legacy of Augustine and the Greek Fathers. Eckhart's theology of suffering provoked varied responses from his students Henry Suso and Johannes Tauler, and the twentieth-century therapist Ursula Fleming. Cusanus provides the volume's lynchpin as two articles analyse his reading of Eriugena and Eckhart, and a third discusses how he deftly countered Johannes Wenck's accusations of heresy. The book will be of interest to students of Medieval Philosophy, Theology, Spirituality and their place within Cultural History. (shrink)

The spectacular and dramatic effects of changing seasons have been a source of inspiration for artists through the ages. Pennsylvania Seasons is a delightful collection of nature-themed poems paired with magisterial landscape photography that captures all the mercurial moods of summer, autumn, winter, and spring. Overflowing with visual and lyric imagery, this book celebrates natural wonders, some preserved in public parks and forests and others lurking in hidden places. Featuring the work of local poets who know the region best, Pennsylvania (...) Seasons matches each photograph with a verse that effectively evokes its power. The result is an inspired ode to nature which will be an essential gift for all Pennsylvanians. (shrink)

This is a slightly, revised version of a paper delivered at the General Assembly of Sapporo Cool Seminar in American Studies. Japan 1981. Reprinted with the permission of the author and the publisher of the lectures in Japan.*2 †From Ideas. Faith, and Feelings: Essays on American Intellectual and Religions History, 1952–1982 by Henry F. May, Copyright © 1983 by Henry F. May. Reprinted by permission of Oxford University Press, Inc.

There is an interesting controversy in recent literature over the nature of Reid's theory of perception. Interpreters are divided over whether Reid's theory of perception is compatible with an acquaintance model of perception. This article discusses Nicholas Wolterstorff's objections to the acquaintance interpretation of Reid. I argue that these objections are inadequate insofar as they do not account for the possibility that Reid offers a ‘state conceptual’ – rather than a ‘state nonconceptual’ – acquaintance theory of perception. I provide textual (...) support for thinking that a state conceptual acquaintance interpretation of Reid is a live possibility, and show how such an interpretation is immune to Wolterstorff's criticisms. (shrink)

Le Traité de Psychopathologie d'Eugene Minkowski se distingue par son caractère très personnel, non moins que par l'ampleur de son information. Cet ouvrage résume l'œuvre d'une vie consacrée à la pratique de la psychothérapie, à la méditation philosophique, et à une active participation aux mouvements intellectuels de l'époque.L'origine de ce livre, nous confie l'auteur, remonte à une promesse faite à Louis Lavelle en 1939, mais il a été rédigé à intervalles irréguliers de 1948 à 1966. Minkowski y a incorporé de (...) nombreux travaux écrits à diverses périodes de sa vie et sur des sujets multiples. (shrink)

Est-il exact que tout système philosophique ne soit, comme le voulait Nietzsche, qu'une confession déguisée? Pour la grande majorité des philosophies, nous ne pouvons répondre à cette question, faute de renseignements suffisants, mais peut-être l'autobiographie de Sartre nous apportera-t-elle une contribution valable. Nous essayerons done de l'examiner comme document historique et comme document psychologique.

Myosin self‐assembly is generally considered to be the major process in thick filament formation within striated muscles. The biological assembly of myosin into thick filaments is being analysed by genetic dissection as well as biochemical and morphological experiments in the nematode Caenorhabditis elegans. This work shows that the assembly of myosin is modulated by its biosynthesis and interaction with non‐myosin proteins. Assemblages which generate multiple nascent thick filaments may play a central role in a catalytic cycle of myosin assembly.

This project was undertaken to develop a telelearning knowledge base aimed at making specialized telelearning knowledge accessible to non-specialized practitioners in the field. The challenge stems from a rationale related to a user-centered approach for the software design process, which is focused on learning in the context of professional practice, the bridge to be built between expert and practitioner knowledge, as well as the knowledge valorization of the latter. In order to take into account users and their situated actions, a (...) usage study was integrated in the analysis phase. This study allows the creation of procedural and contextual telelearning models, and also lists of needs. These results serve as a basis for formulating guidelines for the development of ontologies, for the design of the telelearning knowledge base user interface and telelearning knowledge base environmental description. This paper presents the guidelines and orientations derived from these models. (shrink)